Increase in end diastolic volume causes an increase in ventricular fiber length, which produces an increase in developed tension. It is a mechanism that matches cardiac output to venous return. The greater the venous return, the greater cardiac output. Changes in contractility shift the Frank-Starling curve upward or downward.
- An increase in contractility
causean increase in cardiac output.
- A decrease in contractility causes a decrease in cardiac output.
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